The hotel is located on Seven Mile Beach. Guests at the Cayman Reef Hotel Grand Cayman will be able to visit the beach, snorkel, and partake in other water sports. They will also be able to go scuba diving. Guests will be able to visit the golf course, museums, and turtle farm, as well as visit George Town to find places to shop and dine. The hotel is only 4 miles from the Owen Roberts International Airport, and just a mile from George Town, both of which are easy to reach with a car. Those without vehicles will be able to use public transportation. Some sites are within walking distance of the Cayman Reef Hotel Grand Cayman.

All of the suites offer private balconies and air conditioning. The suites at the Cayman Reef Hotel Grand Cayman offer ceiling fans, sofa beds in the living room, iron and ironing board, in room safe, TV, and wireless Internet.

The Cayman Reef Hotel Grand Cayman offers a full service spa, as well as swimming pools. Guests can utilize the babysitting services as well as the same day laundry service. The hotel also has onsite dining and drinking venues.